Synaptic basis of network dysfunction in neurodevelopmental disorders

“We are who we are because of what we learn and what we remember. We are our synapses!”

Eric Kandel

How do neurons communicate with each other? What happens when communication goes awry? Understanding neuronal communication is the main interest of our lab. In our research group we aim to unravel the molecular mechanisms underlying neuronal communication at the synapse and neuronal network level. We do this through innovative and creative research in a collaborative and challenging environment by studying animal and human cellular models of neurodevelopmental disorders.

Nael Nadif Kasri

Group Leader

Dept Human Genetics

Cognitive Neurosciences


Donders Institute for Brain, Cognition and Behaviour

Geert Grooteplein 21, Route 855

6500 HB Nijmegen

P.O. Box 9101

+31 243614242

Protocol describing how to grow induced human neurons on micro-electrode arrays (MEAs)

Our lab on Dutch regional television:

Trots op Gelderland

(from minute 7)

Nael talking on webinar organised by Genespark on the identification of drug hits for Kleefstra syndrome

Brain-on-a-dish research for epilepsy on Dutch national TV

Lecturer of the Year Award Master Molecular Mechanism of Disease Radboudumc