Synaptic basis of network dysfunction in neurodevelopmental disorders

“We are who we are because of what we learn and what we remember. We are our synapses!”

Eric Kandel

How do neurons communicate with each other? What happens when communication goes awry? Understanding neuronal communication is the main interest of our lab. In our research group we aim to unravel the molecular mechanisms underlying neuronal communication at the synapse and neuronal network level. We do this through innovative and creative research in a collaborative and challenging environment by studying animal and human cellular models of neurodevelopmental disorders.

Nael Nadif Kasri

Prof. Medical Neuroscience

Dept Human Genetics &

Cognitive Neurosciences


Donders Institute for Brain, Cognition and Behaviour

Geert Grooteplein 21, Route 855

6500 HB Nijmegen

P.O. Box 9101

+31 243614242


About the lab

About the PI

New study on characterizing the function of SETD1A in iPSC-derived neurons

FriendlyClearMap: an optimized toolkit for brain mapping analysis

An in silico and in vitro human neuronal network model reveals cellular mechanisms underlying Dravet syndrome